Causal Evidence for a Neural Component of Spatially Global Hemodynamic Signals

Neuron. 2018 Feb 21;97(4):734-736. doi: 10.1016/j.neuron.2018.02.003.

Abstract

In this issue of Neuron, Turchi et al. (2018) reversibly inactivate the basal forebrain to show that this region magnifies global neocortical signal fluctuations without altering the topography of canonical resting-state networks. Thus, spatially diffuse signals measurable via functional neuroimaging may track large-scale neuromodulatory state changes in the primate brain.

Keywords: acetylcholine; basal forebrain; fMRI; global signal; resting-state networks.

Publication types

  • Comment

MeSH terms

  • Animals
  • Basal Forebrain*
  • Brain
  • Functional Neuroimaging
  • Hemodynamics
  • Magnetic Resonance Imaging*
  • Nerve Net