In this issue of Neuron, Turchi et al. (2018) reversibly inactivate the basal forebrain to show that this region magnifies global neocortical signal fluctuations without altering the topography of canonical resting-state networks. Thus, spatially diffuse signals measurable via functional neuroimaging may track large-scale neuromodulatory state changes in the primate brain.
Keywords: acetylcholine; basal forebrain; fMRI; global signal; resting-state networks.
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