Causal Evidence for a Neural Component of Spatially Global Hemodynamic Signals

Neuron. 2018 Feb 21;97(4):734-736. doi: 10.1016/j.neuron.2018.02.003.


In this issue of Neuron, Turchi et al. (2018) reversibly inactivate the basal forebrain to show that this region magnifies global neocortical signal fluctuations without altering the topography of canonical resting-state networks. Thus, spatially diffuse signals measurable via functional neuroimaging may track large-scale neuromodulatory state changes in the primate brain.

Keywords: acetylcholine; basal forebrain; fMRI; global signal; resting-state networks.

Publication types

  • Comment

MeSH terms

  • Animals
  • Basal Forebrain*
  • Brain
  • Functional Neuroimaging
  • Hemodynamics
  • Magnetic Resonance Imaging*
  • Nerve Net