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. 2018 Feb 21;97(4):734-736.
doi: 10.1016/j.neuron.2018.02.003.

Causal Evidence for a Neural Component of Spatially Global Hemodynamic Signals

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Causal Evidence for a Neural Component of Spatially Global Hemodynamic Signals

Kathrin Müsch et al. Neuron. .

Abstract

In this issue of Neuron, Turchi et al. (2018) reversibly inactivate the basal forebrain to show that this region magnifies global neocortical signal fluctuations without altering the topography of canonical resting-state networks. Thus, spatially diffuse signals measurable via functional neuroimaging may track large-scale neuromodulatory state changes in the primate brain.

Keywords: acetylcholine; basal forebrain; fMRI; global signal; resting-state networks.

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