Molecular Cogs: Interplay between Circadian Clock and Cell Cycle

Trends Cell Biol. 2018 May;28(5):368-379. doi: 10.1016/j.tcb.2018.01.006. Epub 2018 Feb 19.


The cell cycle and the circadian clock operate as biological oscillators whose timed functions are tightly regulated. Accumulating evidence illustrates the presence of molecular links between these two oscillators. This mutual interplay utilizes various coupling mechanisms, such as the use of common regulators. The connection between these two cyclic systems has unique interest in the context of aberrant cell proliferation since both of these oscillators are frequently misregulated in cancer cells. Further studies will provide deeper understanding of the detailed molecular connections between the cell cycle and the circadian clock and may also serve as a basis for the design of innovative therapeutic strategies.

Publication types

  • Review

MeSH terms

  • ARNTL Transcription Factors / chemistry
  • ARNTL Transcription Factors / genetics*
  • Animals
  • CLOCK Proteins / genetics*
  • Cell Cycle / genetics*
  • Cell Division / genetics
  • Cell Proliferation / genetics
  • Circadian Clocks / genetics*
  • Circadian Rhythm / genetics
  • Humans


  • ARNTL Transcription Factors
  • CLOCK Proteins