Metabolic and Hypertensive Complications of Pregnancy in Women with Nephrolithiasis

Clin J Am Soc Nephrol. 2018 Apr 6;13(4):612-619. doi: 10.2215/CJN.12171017. Epub 2018 Feb 22.


Background and objectives: Kidney stones are associated with future development of hypertension, diabetes, and the metabolic syndrome. Our objective was to assess whether stone formation before pregnancy was associated with metabolic and hypertensive complications in pregnancy. We hypothesized that stone formation is a marker of metabolic disease and would be associated with higher risk for maternal complications in pregnancy.

Design, setting, participants, & measurements: We conducted a retrospective cohort study of women who delivered infants at the Massachusetts General Hospital from 2006 to 2015. Women with abdominal imaging (computed tomography or ultrasound) before pregnancy were included in the analysis. Pregnancy outcomes in women with documented kidney stones on imaging (stone formers, n=166) were compared with those of women without stones on imaging (controls, n=1264). Women with preexisting CKD, hypertension, and diabetes were excluded.

Results: Gestational diabetes and preeclampsia were more common in stone formers than nonstone formers (18% versus 6%, respectively; P<0.001 and 16% versus 8%, respectively; P=0.002). After multivariable adjustment, previous nephrolithiasis was associated with higher risks of gestational diabetes (adjusted odds ratio, 3.1; 95% confidence interval, 1.8 to 5.3) and preeclampsia (adjusted odds ratio, 2.2; 95% confidence interval, 1.3 to 3.6). Infants of stone formers were born earlier (38.7±2.0 versus 39.2±1.7 weeks, respectively; P=0.01); however, rates of small for gestational age offspring and neonatal intensive care admission were similar between groups (8% versus 7%, respectively; P=0.33 and 10% versus 6%, respectively; P=0.08). First trimester body mass index significantly influenced the association between stone disease and hypertensive complications of pregnancy: in a multivariable linear regression model, stone formation acted as an effect modifier of the relationship between maximum systolic BP in the third trimester and body mass index (P interaction <0.001).

Conclusions: In women without preexisting diabetes, hypertension, and CKD, a history of nephrolithiasis was associated with gestational diabetes and hypertensive disorders of pregnancy, especially in women with high first trimester body mass index.

Keywords: Body Mass Index; Diabetes, Gestational; Female; Gestational Age; Hospitals, General; Humans; Infant, Newborn; Intensive Care, Neonatal; Kidney Calculi; Linear Models; Massachusetts; Metabolic Syndrome; Pre-Eclampsia; Pregnancy Outcome; Pregnancy Trimester, Third; Renal Insufficiency, Chronic; Retrospective Studies; Tomography; blood pressure; gestational diabetes; hypertension; kidney stones; preeclampsia; pregnancy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Pressure*
  • Body Mass Index
  • Boston / epidemiology
  • Case-Control Studies
  • Diabetes, Gestational / epidemiology*
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Small for Gestational Age
  • Intensive Care Units, Neonatal
  • Kidney Calculi / diagnostic imaging
  • Kidney Calculi / epidemiology*
  • Parturition
  • Patient Admission
  • Pre-Eclampsia / epidemiology*
  • Pregnancy
  • Pregnancy Trimester, First
  • Pregnancy Trimester, Third / physiology*
  • Retrospective Studies
  • Risk Factors