The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women

Lasers Med Sci. 2018 Aug;33(6):1245-1254. doi: 10.1007/s10103-018-2465-1. Epub 2018 Feb 23.


Investigations suggest the benefits of low-level laser therapy (LLLT) to improve noninvasive body contouring treatments, inflammation, insulin resistance and to reduce body fat. However, the mechanism for such potential effects in association with exercise training (ET) and possible implications in browning adiposity processes remains unclear. Forty-nine obese women were involved, aged between 20 and 40 years with a body mass index (BMI) of 30-40 kg/m2. The volunteers were divided into Phototherapy (808 nm) and SHAM groups. Interventions consisted of exercise training and phototherapy applications post exercise for 4 months, with three sessions/week. Body composition, lipid profile, insulin resistance, atrial natriuretic peptide (ANP), WNT5 signaling, interleukin-6 (IL-6), and fibroblast growth factor-21 (FGF-21) were measured. Improvements in body mass, BMI, body fat mass, lean mass, visceral fat, waist circumference, insulin, HOMA-IR, total cholesterol, LDL-cholesterol, triglycerides, and ANP in both groups were demonstrated. Only the Phototherapy group showed a reduction in interleukin-6 and an increase in WNT5 signaling. In addition, it was possible to observe a higher magnitude change for the fat mass, insulin, HOMA-IR, and FGF-21 variables in the Phototherapy group. In the present investigation, it was demonstrated that exercise training associated with LLLT promotes an improvement in body composition and inflammatory processes as previously demonstrated. The Phototherapy group especially presented positive modifications of WNT5 signaling, FGF-21, and ANP, possible biomarkers associated with browning adiposity processes. This suggests that this kind of intervention promotes results applicable in clinical practice to control obesity and related comorbidities.

Keywords: Adipose tissue; Browning; Obesity; Phototherapy; Physical exercise.

Publication types

  • Clinical Trial

MeSH terms

  • Adipose Tissue / pathology*
  • Adult
  • Biomarkers / metabolism*
  • Body Mass Index
  • Cell Transdifferentiation / radiation effects*
  • Exercise / physiology*
  • Female
  • Humans
  • Inflammation
  • Insulin / metabolism
  • Insulin Resistance
  • Intra-Abdominal Fat
  • Low-Level Light Therapy*
  • Obesity / physiopathology*
  • Obesity / radiotherapy*
  • Phototherapy
  • Signal Transduction
  • Wnt-5a Protein / metabolism
  • Young Adult


  • Biomarkers
  • Insulin
  • Wnt-5a Protein