PharmGKB: A worldwide resource for pharmacogenomic information

Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. doi: 10.1002/wsbm.1417. Epub 2018 Feb 23.


As precision medicine becomes increasingly relevant in healthcare, the field of pharmacogenomics (PGx) also continues to gain prominence in the clinical setting. Leading institutions have begun to implement PGx testing and the amount of published PGx literature increases yearly. The Pharmacogenomics Knowledgebase (PharmGKB; is one of the foremost worldwide resources for PGx knowledge, and the organization has been adapting and refocusing its mission along with the current revolution in genomic medicine. The PharmGKB website provides a diverse array of PGx information, from annotations of the primary literature to guidelines for adjusting drug treatment based on genetic information. It is freely available and accessible to everyone from researchers to clinicians to everyday citizens. PharmGKB was found over 17 years ago, but continues to be a vital resource for the entire PGx community and the general public. This article is categorized under: Translational, Genomic, and Systems Medicine > Translational Medicine.

Keywords: pharmGKB; pharmacodynamics; pharmacogenetics; pharmacogenomics; pharmacokinetics.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Databases, Factual
  • Germ Cells / metabolism
  • Guidelines as Topic
  • HLA-B Antigens / genetics
  • HLA-B Antigens / metabolism
  • Humans
  • Pharmacogenetics*
  • Pharmacokinetics
  • Precision Medicine*


  • HLA-B Antigens