Predisposing and precipitating factors for delirium in community-dwelling older adults admitted to hospital with this condition: A prospective case series

PLoS One. 2018 Feb 23;13(2):e0193034. doi: 10.1371/journal.pone.0193034. eCollection 2018.


Background: Factors associated with delirium among community-dwelling older adults have been poorly studied. Our aim was to describe the prevalence of predisposing and precipitating factors for delirium among patients admitted for delirium and to assess whether these factors were appropriately recognized at the first patient assessment at hospital.

Methods: Consecutive community-dwelling individuals admitted to three geriatric acute care units with a confirmed initial diagnosis of delirium were prospectively included. An independent investigator recorded, using a predefined form, any acute medical condition considered by the attending geriatrician to be a precipitating factor, at the first patient assessment and at the end of his stay in acute care.

Results: A total of 208 patients were included, 80.0% had a pre-existing cognitive or neurological disorder, or both. The most frequent precipitating factor found were infections (49.0% of all patients, mainly lung and urinary tract infections), followed by drugs (30.8%), dehydration (26.4%) and electrolytic disturbances (18.7%, mostly hyponatremia). 91% of patients had a cerebral imagery, but acute neurological conditions were found in only 18.3%. Fewer precipitating factors were found at first than at final assessment (1.4 (95%CI 1.3-1.6) versus 1.9 (95%CI 1.8-2.0) respectively, p<0.001). This difference was significant for all main categories of precipitating factors.

Conclusions: Infections, followed by drugs and hydro-electrolytic disorders seem to be the most frequent precipitating factors for delirium in community-dwelling elderly individuals. Early diagnostic and management of precipitating factors in these patients should be improved, as a significant number of them are missed at the initial assessment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Delirium / diagnosis
  • Delirium / etiology*
  • Drug-Related Side Effects and Adverse Reactions / complications
  • Female
  • Hospitalization
  • Humans
  • Independent Living
  • Infections / complications
  • Male
  • Paris
  • Precipitating Factors
  • Prospective Studies
  • Water-Electrolyte Imbalance / complications

Grant support

This work was supported by the Sorbonne Universités, Université Paris 6 Pierre et Marie Curie (UPMC, and the Assistance Publique – Hôpitaux de Paris (APHP, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.