Genome Writing: Current Progress and Related Applications

Genomics Proteomics Bioinformatics. 2018 Feb;16(1):10-16. doi: 10.1016/j.gpb.2018.02.001. Epub 2018 Feb 21.


The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field. Finally, we discuss current challenges and future prospects.

Keywords: Bioethics; Biosafety; Genome editing; Genome writing; Synthetic biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CRISPR-Cas Systems*
  • Gene Editing / methods*
  • Genetic Engineering / methods*
  • Genome, Human*
  • High-Throughput Nucleotide Sequencing*
  • Humans