Claudins: a tale of interactions in the thick ascending limb

Kidney Int. 2018 Mar;93(3):535-537. doi: 10.1016/j.kint.2017.09.032.


The claudins are the main proteins composing the tight junctions. The differential expression of claudin isoforms contributes to the specificity of paracellular transport pathways along the kidney tubule. Recent studies focusing on claudin-10 and claudin-16 support the longitudinal specialization of paracellular transport of cations within the thick ascending limb and demonstrate that complex tubular adaptations operate to buffer the consequences of chronic segmental lesions in the kidney.

Publication types

  • Comment

MeSH terms

  • Claudins*
  • Kidney
  • Kidney Tubules
  • Protein Isoforms
  • Tight Junctions*


  • Claudins
  • Protein Isoforms