Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jun;28(6):436-453.
doi: 10.1016/j.tcb.2018.02.001. Epub 2018 Feb 21.

Hallmarks of Cellular Senescence

Affiliations
Review

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al. Trends Cell Biol. .

Abstract

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the identification, characterization, and pharmacological elimination of senescent cells have gained attention in the field of aging research. However, the nonspecificity of current senescence markers and the existence of different senescence programs strongly limit these tasks. Here, we describe the molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo. We also highlight the importance that these levels of regulations have in the development of therapeutic targets.

Similar articles

See all similar articles

Cited by 91 articles

See all "Cited by" articles

LinkOut - more resources

Feedback