Multifunctional manganese-doped Prussian blue nanoparticles for two-photon photothermal therapy and magnetic resonance imaging

Abstract

Here we demonstrate for the first time that Mn²⁺-doped Prussian blue nanoparticles of c.a. 70 nm act as effective agents for photothermal therapy under two-photon excitation with an almost total eradication of malignant cells (97 and 98%) at a concentration of 100 μg mL^-1 24 h after NIR excitation. This effect combined with interesting longitudinal NMR relaxivity values offer new perspectives for effective imaging and cancer treatment.

Keywords: Cancer cells’ eradication; MRI; Multifunctional; Nanoparticles; Photo-thermal agent; Photo-thermal therapy; Prussian blue; Two-photon irradiation.