Full-Field-of-View Time-Harmonic Elastography of the Native Kidney

Ultrasound Med Biol. 2018 May;44(5):949-954. doi: 10.1016/j.ultrasmedbio.2018.01.007. Epub 2018 Feb 22.


The purpose of this study was to analyze full-field-of-view maps of renal shear wave speed (SWS) measured by time-harmonic elastography (THE) in healthy volunteers in terms of reproducibility, regional variation and physiologic effects. The kidneys of 37 healthy volunteers were investigated by multifrequency THE. The complete renal parenchyma, as well as cortex and medulla, was analyzed. A subgroup was investigated to test reproducibility (n = 3). Significant differences between SWS in cortex, medulla and full parenchyma were observed (2.10 ± 0.17, 1.35 ± 0.11 and 1.71 ± 0.16 m/s, all p values < 0.001) with mean intra-volunteer standard deviations of repeated measurements of 0.04 m/s (1.6%), 0.06 m/s (4.0%) and 0.08 m/s (4.5%), respectively. No effects of kidney anatomy, age, body mass index, blood pressure and heart rate on SWS were observed. THE allows generation of full-field-of-view SWS maps of native kidneys with high reproducibility.

Keywords: Cortex; Medulla; Multifrequency vibration; Native kidney; Renal stiffness; Shear wave speed; Time-harmonic elastography; Tissue mechanical parameters; Ultrasound; Ultrasound elastography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Elasticity Imaging Techniques / methods*
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Kidney / anatomy & histology*
  • Male
  • Middle Aged
  • Prospective Studies
  • Reference Values
  • Reproducibility of Results
  • Young Adult