Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 10, 16
eCollection

Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease

Affiliations
Review

Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease

Marco Cascella et al. Front Aging Neurosci.

Abstract

Several nutraceuticals have been investigated for preventing or retarding the progression of different neurodegenerative diseases, including Alzheimer's disease (AD). Because Nigella sativa (NS) and its isolated compound thymoquinone (TQ) have significant anti-oxidant and anti-inflammatory proprieties, they could represent effective neuroprotective agents. The purpose of this manuscript is to analyze and to recapitulate the results of in vitro and in vivo studies on the potential role of NS/TQ in AD's prevention and treatment. The level of evidence for each included animal study has been assessed by using a modified CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) 10-item checklist. We used MEDLINE and EMBASE databases to screen relevant articles published up to July 2017. A manual search was also performed. The database search yielded 38 studies, of which 18 were included in this manuscript. Results from these approaches suggest that NS or TQ could represent an effective strategy against AD due to the balancing of oxidative processes and the binding to specific intracellular targets. The overall effects mainly regard the prevention of hippocampal pyramidal cell loss and the increased cognitive functions.

Keywords: Alzheimer's disease; Nigella sativa; natural compounds; oxidative stress; thymoquinone.

Figures

Figure 1
Figure 1
PRISMA flow diagram.

Similar articles

See all similar articles

Cited by 4 PubMed Central articles

References

    1. Abdel-Fattah A. M., Matsumoto K., Watanabe H. (2000). Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Eur. J. Pharmacol. 400, 89–97. 10.1016/S0014-2999(00)00340-X - DOI - PubMed
    1. Agostinho P., Cunha R. A., Oliveira C. (2010). Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. Curr. Pharm. Des. 16, 2766–2778. 10.2174/138161210793176572 - DOI - PubMed
    1. Aisen P. S., Schneider L. S., Sano M., Diaz-Arrastia R., van Dyck C. H., Weiner M. F., et al. . (2008). High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 300, 1774–1783. 10.1001/jama.300.15.1774 - DOI - PMC - PubMed
    1. Akram Khan M., Afzal M. (2016). Chemical composition of Nigella sativa Linn: part 2 recent advances. Inflammopharmacology 24, 67–79. 10.1007/s10787-016-0262-7 - DOI - PMC - PubMed
    1. Alhebshi A. H., Gotoh M., Suzuki I. (2013). Thymoquinone protects cultured rat primary neurons against amyloid beta-induced neurotoxicity. Biochem. Biophys. Res. Commun. 433, 362–367. 10.1016/j.bbrc.2012.11.139 - DOI - PubMed
Feedback