Several nutraceuticals have been investigated for preventing or retarding the progression of different neurodegenerative diseases, including Alzheimer's disease (AD). Because Nigella sativa (NS) and its isolated compound thymoquinone (TQ) have significant anti-oxidant and anti-inflammatory proprieties, they could represent effective neuroprotective agents. The purpose of this manuscript is to analyze and to recapitulate the results of in vitro and in vivo studies on the potential role of NS/TQ in AD's prevention and treatment. The level of evidence for each included animal study has been assessed by using a modified CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) 10-item checklist. We used MEDLINE and EMBASE databases to screen relevant articles published up to July 2017. A manual search was also performed. The database search yielded 38 studies, of which 18 were included in this manuscript. Results from these approaches suggest that NS or TQ could represent an effective strategy against AD due to the balancing of oxidative processes and the binding to specific intracellular targets. The overall effects mainly regard the prevention of hippocampal pyramidal cell loss and the increased cognitive functions.
Keywords: Alzheimer's disease; Nigella sativa; natural compounds; oxidative stress; thymoquinone.
Thymoquinone a Potential Therapeutic Molecule From the Plant Nigella Sativa: Role of Colloidal Carriers in Its Effective DeliveryP Negi et al. Recent Pat Drug Deliv Formul 12 (1), 3-22. PMID 29189187. - ReviewThe findings of this review confirm the effectiveness of TQ in various pathologies viz. inflammation, cancer, diabetes, gastric, hepatic, microbial and allergies. However …
Role of Nigella Sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences From Experimental Animal StudiesM Cascella et al. Nutrients 9 (6). PMID 28629150. - ReviewExperimental animal studies showed the protective effect of NS, or TQ, on chemotherapy-induced nephrotoxicity. These effects are caused by decreasing lipid peroxidation a …
The Effects of Nigella Sativa Hydro-Alcoholic Extract and Thymoquinone on Lipopolysaccharide - Induced Depression Like Behavior in RatsM Hosseini et al. J Pharm Bioallied Sci 4 (3), 219-25. PMID 22923964.The results of the present study showed that hydro-alcoholic extract of Nigella sativa can prevent LPS-induced depression like behavior in rats. These results support the …
Review on Clinical Trials of Black Seed (Nigella Sativa ) and Its Active Constituent, ThymoquinoneA Tavakkoli et al. J Pharmacopuncture 20 (3), 179-193. PMID 30087794. - ReviewSome effects of N. sativa, such as its hypoglycemic, hypolipidemic and bronchodilatory effects, have been sufficiently studied and are sufficiently understood to a …
Protective Effect of Nigella Sativa and Thymoquinone on Serum/Glucose Deprivation-Induced DNA Damage in PC12 CellsB Babazadeh et al. Avicenna J Phytomed 2 (3), 125-32. PMID 25050241.These data indicate that NSE and TQ have a genoprotective property, as revealed by the comet assay, under SGD condition in PC12 cells.
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