Reconciliation of pH, conductivity, total organic carbon with carboxylic acids detected by ion chromatography in solution after contact with multilayer films after γ-irradiation

Eur J Pharm Sci. 2018 May 30:117:216-226. doi: 10.1016/j.ejps.2018.02.023. Epub 2018 Feb 23.

Abstract

The impact of γ-irradiation on polymers in multilayer films was studied by means of the study of the diffusion and release (spontaneous migration of the molecules from the container into the product) of chemical species in aqueous solution. A series of different measurements have been performed: pH, conductivity, total organic carbon (TOC) and ion chromatography (IC). Their evolution according to γ-irradiation dose was studied. More several rinsings made over several months allowed to quantify well the impact of the irradiation on these polymers. The samples are irradiated at several γ-doses, up to 270 kGy, and compared with a non-irradiated sample used as reference. It shows that quantity of generated carboxylic acids depends on the film material (PE/EVOH/PE and EVA/EVOH/EVA) and increases with γ-dose.

Keywords: Carboxylic acid; Ethylene vinyl acetate; Ion chromatography; Polyethylene; γ-Irradiation.

Publication types

  • Comparative Study

MeSH terms

  • Carboxylic Acids / chemistry
  • Carboxylic Acids / radiation effects*
  • Chromatography / methods*
  • Diffusion
  • Disposable Equipment*
  • Dose-Response Relationship, Radiation
  • Drug Packaging*
  • Electric Conductivity
  • Gamma Rays*
  • Hydrogen-Ion Concentration
  • Models, Chemical
  • Polyethylene / chemistry
  • Polyethylene / radiation effects*
  • Polyvinyls / chemistry
  • Polyvinyls / radiation effects*
  • Principal Component Analysis
  • Time Factors

Substances

  • Carboxylic Acids
  • Polyvinyls
  • Polyethylene