Quantitative Assessment of Gynecologic Malignancies

Abstract

¹⁸F-fluorodeoxyglucose PET/CT as a dual-modality imaging, plays a key role in the diagnosis, staging, response assessment, and disease surveillance. Uptake by tumor cells offers an opportunity to differentiate viable malignant cells from posttreatment effects. ¹⁸F-fluorodeoxyglucose PET/CT-based criteria have been developed to evaluate treatment response. Uptake can reflect the biologic aggressiveness of the tumor, predicting the risk of metastasis and recurrence. The standardized uptake value can be measured as maximum, mean, or peak. Volumetric uptake measurements have shown substantial promise in providing accurate tumor assessment. We discuss these quantitative parameters in the assessment of gynecologic malignancies.

Keywords: FDG; Gynecologic malignancies; Metabolic tumor volume; PET/CT; Standardized uptake value; Total lesion glycolysis.