Plasma Levels of Rifampin Correlate with the Tuberculosis Drug Activity Assay

Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00218-18. doi: 10.1128/AAC.00218-18. Print 2018 May.

Abstract

The plasma tuberculosis drug activity (TDA) assay may be an alternative tool for therapeutic drug monitoring in resource-limited settings. In tuberculosis (TB) patients (n = 30), TDA and plasma levels of first-line drugs were analyzed 2 h postdose, 2 weeks after treatment initiation. Patients with plasma levels of rifampin lower than 8 mg/liter had a significantly lower median TDA (1.40 versus 1.68, P = 0.0013). TDA may be used to identify TB patients with suboptimal rifampin levels during TB treatment.

Keywords: Mycobacterium tuberculosis; isoniazid; pharmacokinetics; rifampin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibiotics, Antitubercular / blood*
  • Antibiotics, Antitubercular / therapeutic use*
  • Drug Monitoring / methods*
  • Female
  • Humans
  • Isoniazid / blood
  • Isoniazid / therapeutic use
  • Male
  • Mycobacterium tuberculosis / drug effects
  • Rifampin / blood*
  • Rifampin / therapeutic use*
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / microbiology

Substances

  • Antibiotics, Antitubercular
  • Isoniazid
  • Rifampin