Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders. In addition, adult neurogenesis might also play a role in mood and affective disorders. The factors that regulate adult neurogenesis have been broadly studied. However, the underlying molecular mechanisms of regulating neurogenesis are still not fully defined. In this review, we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine neurogenesis. We will further discuss pre-clinical and clinical studies that have investigated the potential of modulating neurogenesis as therapeutic intervention in neurodegeneration.
Keywords: Cytokines; Extrinsic factors; Neurotrophins; Niche; Stem cells; Therapy; Transcription factors.
Conflict of interest statement
not applicablenot applicable“The authors declare that they have no competing interests”
Social Cues, Adult Neurogenesis, and Reproductive BehaviorP Peretto et al. PMID 24830028. - ReviewAdult neurogenesis is a striking form of neural plasticity occurring in restricted regions of the mammalian brain. The past decades have witnessed tremendous research eff …
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Cited by 7 PubMed Central articles
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