Interplay of vitamin D, vitamin B12, homocysteine and bone mineral density in postmenopausal females

Health Care Women Int. 2018 Dec;39(12):1340-1349. doi: 10.1080/07399332.2018.1444042. Epub 2018 Mar 20.


Osteoporosis is most common age related, multifactorial disease. The aim of the researchers were to discover the association between serum homocysteine, vitamin D, vitamin B12 and bone mineral density in postmenopausal non-osteoporotic and osteoporotic females. In this cross- sectional study, 156 postmenopausal females between 50-70 years of age were recruited and divided into two groups, non-osteoporotic (n = 52) and osteoporotic (n = 104). There was significant negative correlation of homocysteine with vitamin D and B12 in postmenopausal non-osteoporotic and homocysteine with vitamin B12 in postmenopausal osteoporotic females. Serum homocysteine levels were predicted by vitamin D in postmenopausal non-osteoporotic and vitamin B12 in postmenopausal osteoporotic females.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Aged
  • Bone Density / physiology*
  • Cross-Sectional Studies
  • Female
  • Homocysteine / blood*
  • Humans
  • Middle Aged
  • Osteoporosis, Postmenopausal / blood*
  • Osteoporosis, Postmenopausal / epidemiology
  • Osteoporosis, Postmenopausal / physiopathology
  • Postmenopause / blood*
  • Vitamin B 12 / blood*
  • Vitamin D / blood*


  • Homocysteine
  • Vitamin D
  • Vitamin B 12