Guiding Mitotic Progression by Crosstalk between Post-translational Modifications

Sabine A G Cuijpers; Alfred C O Vertegaal

doi:10.1016/j.tibs.2018.02.004

Guiding Mitotic Progression by Crosstalk between Post-translational Modifications

Trends Biochem Sci. 2018 Apr;43(4):251-268. doi: 10.1016/j.tibs.2018.02.004. Epub 2018 Feb 24.

Authors

Sabine A G Cuijpers¹, Alfred C O Vertegaal²

Affiliations

¹ Department of Molecular Cell Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
² Department of Molecular Cell Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. Electronic address: vertegaal@lumc.nl.

PMID: 29486978
DOI: 10.1016/j.tibs.2018.02.004

Abstract

Cell division is tightly regulated to disentangle copied chromosomes in an orderly manner and prevent loss of genome integrity. During mitosis, transcriptional activity is limited and post-translational modifications (PTMs) are responsible for functional protein regulation. Essential mitotic regulators, including polo-like kinase 1 (PLK1) and cyclin-dependent kinases (CDK), as well as the anaphase-promoting complex/cyclosome (APC/C), are members of the enzymatic machinery responsible for protein modification. Interestingly, communication between PTMs ensures the essential tight and timely control during all consecutive phases of mitosis. Here, we present an overview of current concepts and understanding of crosstalk between PTMs regulating mitotic progression.

Keywords: Mitosis; SUMO; crosstalk; phosphorylation; post-translational modifications; ubiquitin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Cycle Proteins / metabolism*
Cyclin-Dependent Kinases / metabolism*
Humans
Mitosis / genetics*
Polo-Like Kinase 1
Protein Processing, Post-Translational* / genetics
Protein Serine-Threonine Kinases / metabolism*
Proto-Oncogene Proteins / metabolism*

Substances

Cell Cycle Proteins
Proto-Oncogene Proteins
Protein Serine-Threonine Kinases
Cyclin-Dependent Kinases