The Mouse Superior Colliculus: An Emerging Model for Studying Circuit Formation and Function

Front Neural Circuits. 2018 Feb 13;12:10. doi: 10.3389/fncir.2018.00010. eCollection 2018.

Abstract

The superior colliculus (SC) is a midbrain area where visual, auditory and somatosensory information are integrated to initiate motor commands. The SC plays a central role in visual information processing in the mouse; it receives projections from 85% to 90% of the retinal ganglion cells (RGCs). While the mouse SC has been a long-standing model used to study retinotopic map formation, a number of technological advances in mouse molecular genetic techniques, large-scale physiological recordings and SC-dependent visual behavioral assays have made the mouse an even more ideal model to understand the relationship between circuitry and behavior.

Keywords: electrophysiology; mouse; retinotopic map; sensorimotor systems; superior colliculus.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Mice
  • Models, Animal
  • Neurons / cytology
  • Neurons / physiology
  • Superior Colliculi / anatomy & histology
  • Superior Colliculi / growth & development*
  • Superior Colliculi / physiology*
  • Visual Pathways / anatomy & histology
  • Visual Pathways / growth & development
  • Visual Pathways / physiology