Lisinopril

Excerpt

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that has been prescribed for nearly 30 years to manage hypertension and reduce cardiovascular strain. As a competitive ACE inhibitor, lisinopril prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This activity reviews lisinopril's mechanism of action, highlighting its distinct pharmacokinetic parameters and half-life compared to other ACE inhibitors. The discussion also includes lisinopril's FDA-approved indications, off-label uses, contraindications, drug-drug interactions, and potential toxicity. Additionally, dosage recommendations, warnings, and necessary patient monitoring protocols are outlined to support safe administration. This activity also emphasizes the critical role of an interprofessional healthcare team in managing hypertension with lisinopril.