Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris

Int J Dermatol. 1986 Dec;25(10):664-7. doi: 10.1111/j.1365-4362.1986.tb04534.x.

Abstract

A 2.5% formulation of benzoyl peroxide was compared with its vehicle, and with a 5% and a 10% proprietary benzoyl peroxide gel preparation in three double-blind studies involving 153 patients with mild to moderately severe acne vulgaris. The 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules). Desquamation, erythema, and symptoms of burning with the 2.5% gel were less frequent than with the 10% preparation but equivalent to the 5% gel. The 2.5% formulation also significantly reduced Propionibacterium acnes and the percentage of free fatty acids in the surface lipids after 2 weeks of topical application.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Acne Vulgaris / complications
  • Acne Vulgaris / drug therapy*
  • Administration, Topical
  • Adult
  • Bacterial Infections / drug therapy*
  • Benzoyl Peroxide / administration & dosage
  • Benzoyl Peroxide / adverse effects
  • Benzoyl Peroxide / therapeutic use*
  • Clinical Trials as Topic
  • Fatty Acids / analysis
  • Female
  • Humans
  • Male
  • Peroxides / therapeutic use*
  • Propionibacterium acnes / drug effects

Substances

  • Fatty Acids
  • Peroxides
  • Benzoyl Peroxide