In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

Alexandra Barbouti; Konstantinos Evangelou; Ioannis S Pateras; Alexandra Papoudou-Bai; Amalia Patereli; Kalliopi Stefanaki; Dimitra Rontogianni; Daniel Muñoz-Espín; Panagiotis Kanavaros; Vassilis G Gorgoulis

doi:10.1016/j.mad.2018.02.005

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

Mech Ageing Dev. 2019 Jan:177:88-90. doi: 10.1016/j.mad.2018.02.005. Epub 2018 Feb 25.

Affiliations

¹ Department of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.
² Department of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: kostasevangelou@cc.uoi.gr.
³ Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
⁴ Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece.
⁵ Department of Pathology, Agia Sophia Hospital, Athens, Greece.
⁶ Department of Anatomic Pathology, Evangelismos General Hospital, University of Athens, Athens, Greece.
⁷ CRUK Cambridge Centre Early Detection Programme, Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK.
⁸ Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK; Biomedical Research Foundation, Academy of Athens, Athens, Greece. Electronic address: vgorg@med.uoa.gr.

PMID: 29490231
DOI: 10.1016/j.mad.2018.02.005

Abstract

Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular senescence is implicated in this process. We demonstrate, for the first time in situ, that cellular senescence occurs during human thymic involution using SenTraGor™, a novel chemical compound that is applicable in archival tissue material, providing thus further insights in thymus histophysiology.

Keywords: Cellular senescence; Lipofuscin; SenTraGor(TM); Thymic involution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cellular Senescence / physiology*
Epithelial Cells / cytology
Epithelial Cells / metabolism*
Humans
Thymus Gland / cytology
Thymus Gland / metabolism*

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

Authors

Affiliations

Abstract

Publication types

MeSH terms

Grants and funding