Ki-67 and Survivin as Predictive Factors for Rectal Cancer Treated with Preoperative Chemoradiotherapy

Anticancer Res. 2018 Mar;38(3):1735-1739. doi: 10.21873/anticanres.12409.

Abstract

Aim: To evaluate the usefulness of Ki-67 index and survivin as predictive prognostic factors for rectal cancer treated with preoperative chemoradiotherapy.

Patients and methods: The Ki-67 index and survivin expression were examined in patients with stage II/III rectal cancer (n=46) by immunohistochemistry. Patients were divided into a high-group and a low-group for the Ki-67 index, and positive and negative groups for survivin expression. Overall and disease-free survival were compared between the groups, and the correlation between Ki-67 index and survivin expression was assessed.

Results: The 5-year disease-free survival rate of the group with high Ki-67 index was significantly lower than that of the group with low Ki-67 index (53% and 88%, p=0.03), as was the 5-year overall survival rate (68% and 100%, p=0.03). Findings for survivin were not significant.

Conclusion: Ki-67 index and survivin may be useful biomarkers for rectal cancer with preoperative CRT.

Keywords: Ki-67 index; pre-operative CRT; rectal cancer; survival; survivin.

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Chemoradiotherapy
  • Disease-Free Survival
  • Female
  • Humans
  • Immunohistochemistry
  • Inhibitor of Apoptosis Proteins / analysis*
  • Ki-67 Antigen / analysis*
  • Middle Aged
  • Neoplasm Staging
  • Predictive Value of Tests
  • Preoperative Period
  • Prognosis
  • Rectal Neoplasms / pathology
  • Rectal Neoplasms / surgery
  • Rectal Neoplasms / therapy*
  • Survivin

Substances

  • BIRC5 protein, human
  • Biomarkers, Tumor
  • Inhibitor of Apoptosis Proteins
  • Ki-67 Antigen
  • Survivin