Non-invasive Intracranial Pressure Assessment in Brain Injured Patients Using Ultrasound-Based Methods

Acta Neurochir Suppl. 2018;126:69-73. doi: 10.1007/978-3-319-65798-1_15.

Abstract

Background: Non-invasive measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Invasive measurement of ICP remains the "gold standard" and should be performed when clinical indications are met, but it is invasive and brings some risks. In this project, we aim to validate the non-invasive ICP (nICP) assessment models based on arterious and venous transcranial Doppler ultrasonography (TCD) and optic nerve sheath diameter (ONSD).

Methods: We included brain injured patients requiring invasive ICP monitoring (intraparenchymal or intraventricular). We assessed the concordance between ICP measured non-invasively with arterious [flow velocity diastolic formula (ICPFVd) and pulsatility index (PI)], venous TCD (vPI) and ICP derived from ONSD (nICPONSD) compared to invasive ICP measurement.

Results: Linear regression showed a positive relationship between nICP and ICP for all the methods, except PIv. ICPONSD showed the strongest correlation with invasive ICP (r = 0.61) compared to the other methods (ICPFVd, r = 0.26, p value = 0.0015; PI, r = 0.19, p value = 0.02, vPI, r = 0.056, p value = 0.510). The ability to predict intracranial hypertension was highest for ICPONSD (AUC = 0.91; 95% CI, 0.85-0.97 at ICP > 20 mmHg), with a sensitivity and specificity of 85%, followed by ICPFVd (AUC = 0.67; 95% CI, 0.54-0.79).

Conclusions: Our results demonstrate that among the non-invasive methods studied, ONSD showed the best accuracy in the detection of ICP.

Keywords: Brain ultrasound; Intracranial pressure; Optic nerve sheath diameter; Transcranial doppler.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain Injuries, Traumatic / complications
  • Brain Injuries, Traumatic / diagnostic imaging*
  • Brain Injuries, Traumatic / physiopathology
  • Cerebral Arteries / diagnostic imaging*
  • Cerebral Veins / diagnostic imaging*
  • Female
  • Humans
  • Intracranial Hypertension / diagnostic imaging*
  • Intracranial Hypertension / etiology
  • Intracranial Hypertension / physiopathology
  • Intracranial Pressure
  • Linear Models
  • Male
  • Middle Aged
  • Monitoring, Physiologic / methods*
  • Optic Nerve / diagnostic imaging*
  • Sensitivity and Specificity
  • Subarachnoid Hemorrhage / complications
  • Subarachnoid Hemorrhage / diagnostic imaging*
  • Subarachnoid Hemorrhage / physiopathology
  • Ultrasonography
  • Ultrasonography, Doppler, Transcranial