Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

Science. 1987 Feb 20;235(4791):880-4. doi: 10.1126/science.2949367.


The amyloid beta protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the beta protein suggests that it derives from a larger protein expressed in a variety of tissues. Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the beta protein maps to chromosome 21. Regional localization of this gene by both physical and genetic mapping places it in the vicinity of the genetic defect causing the inherited form of Alzheimer's disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alzheimer Disease / genetics*
  • Amino Acid Sequence
  • Amyloid / genetics*
  • Amyloidosis / genetics
  • Brain / physiopathology
  • Chromosome Mapping
  • Chromosomes, Human, Pair 21*
  • DNA / genetics
  • Down Syndrome / genetics
  • Gene Expression Regulation
  • Genetic Linkage
  • Humans
  • RNA, Messenger / genetics
  • Tissue Distribution
  • Transcription, Genetic


  • Amyloid
  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/M15532