Lewy Body Dementia (LBD) encompasses two clinical entities, namely dementia with Lewy bodies and Parkinson disease dementia. It is a progressive degenerative brain disorder characterized by dementia, psychosis, and features of parkinsonism. Symptoms fluctuate with time and vary among different individuals. Diagnosis of LBD requires thorough clinical examination as many of its features overlap with other dementia disorders. It is the third most common type of dementia after Alzheimer disease and Vascular dementia. It characterizes by the deposition of Lewy bodies in the brain that are intraneuronal cytoplasmic inclusion bodies having aggregates of alpha-synuclein and ubiquitin. There continues to be a debate between the relationship between Parkinson disease and LBD. The latest LBD consortium has set an arbitrary 12-month rule to differentiate LBD from Parkinson disease with dementia. If the patient has Parkinson disease for 12 months or longer before any cognitive impairment is noticed, then the disorder is most likely Parkinson disease with dementia, if the time period is shorter then the disorder is LBD. In most cases of LBD, dementia precedes the motor signs, particularly episodes of diminished responsiveness and visual hallucinations.
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Dementia With Lewy Bodies and Parkinson's Disease-Dementia: Current Concepts and ControversiesKA Jellinger. J Neural Transm (Vienna) 125 (4), 615-650. PMID 29222591. - ReviewDementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although sharing many clinical, neurochemical and morphological features, according to DSM-5, are …
Lewy- And Alzheimer-type Pathologies in Midbrain and Cerebellum Across the Lewy Body Disorders SpectrumM Sierra et al. Neuropathol Appl Neurobiol 42 (5), 451-62. PMID 26810462.Frequency and severity of Aβ and tau pathologies in the midbrain across the LBD-spectrum were midway between controls and AD, with Aβ in the tectum/tegmentum being associ …
Regional Overlap of Pathologies in Lewy Body DisordersM Colom-Cadena et al. J Neuropathol Exp Neurol 76 (3), 216-224. PMID 28395086.Lewy body disorders (LBD) are common neurodegenerative diseases characterized by the presence of aggregated α-synuclein in Lewy bodies and Lewy neurites in the central an …
Are Dementia With Lewy Bodies and Parkinson's Disease Dementia the Same Disease?KA Jellinger et al. BMC Med 16 (1), 34. PMID 29510692.DLB and PDD are important dementia syndromes that overlap in many clinical features, genetics, neuropathology, and management. They are currently considered as subtypes o …
Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease DementiaSN Gomperts. Continuum (Minneap Minn) 22 (2 Dementia), 435-63. PMID 27042903. - ReviewDLB and PDD are important and common dementia syndromes that overlap in their clinical features, neuropathology, and management. They are believed to exist on a spectrum …