Remote magnetic actuation using a clinical scale system

PLoS One. 2018 Mar 1;13(3):e0193546. doi: 10.1371/journal.pone.0193546. eCollection 2018.

Abstract

Remote magnetic manipulation is a powerful technique for controlling devices inside the human body. It enables actuation and locomotion of tethered and untethered objects without the need for a local power supply. In clinical applications, it is used for active steering of catheters in medical interventions such as cardiac ablation for arrhythmia treatment and for steering of camera pills in the gastro-intestinal tract for diagnostic video acquisition. For these applications, specialized clinical-scale field applicators have been developed, which are rather limited in terms of field strength and flexibility of field application. For a general-purpose field applicator, flexible field generation is required at high field strengths as well as high field gradients to enable the generation of both torques and forces on magnetic devices. To date, this requirement has only been met by small-scale experimental systems. We have built a highly versatile clinical-scale field applicator that enables the generation of strong magnetic fields as well as strong field gradients over a large workspace. We demonstrate the capabilities of this coil-based system by remote steering of magnetic drills through gel and tissue samples with high torques on well-defined curved trajectories. We also give initial proof that, when equipped with high frequency transmit-receive coils, the machine is capable of real-time magnetic particle imaging while retaining a clinical-scale bore size. Our findings open the door for image-guided radiation-free remote magnetic control of devices at the clinical scale, which may be useful in minimally invasive diagnostic and therapeutic medical interventions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Equipment Design
  • Humans
  • Image Interpretation, Computer-Assisted / instrumentation
  • Magnetic Resonance Imaging / instrumentation
  • Magnetics / instrumentation*
  • Remote Sensing Technology / instrumentation*
  • Torque

Grants and funding

This work was supported by Bundesministerium für Bildung und Forschung (German Federal Ministry of Education and Research), Grant numbers 13GW0069C and 13N11086. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Philips GmbH Market DACH: The funder provided support in the form of salaries for author CS, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Philips GmbH Innovative Technologies: The funder provided support for authors JR and BG, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the author contributions section.