Surface marker profiles on lung lymphocytes may predict the mechanism of immune-mediated pneumonitis triggered by tumor-infiltrating lymphocytes in lung cancer patients treated with pembrolizumab

Lung Cancer. 2018 Apr:118:171-172. doi: 10.1016/j.lungcan.2018.02.012. Epub 2018 Feb 21.

Authors

Keishi Oda¹, Kaori Kato¹, Midori Nakamura¹, Takanobu Jotatsu¹, Shingo Noguchi¹, Toshinori Kawanami¹, Takashi Kido¹, Kazuhiro Yatera²

Affiliations

¹ Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka 807-8555, Japan.
² Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka 807-8555, Japan. Electronic address: yatera@med.uoeh-u.ac.jp.

PMID: 29496324
DOI: 10.1016/j.lungcan.2018.02.012

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adenocarcinoma of Lung / diagnosis
Adenocarcinoma of Lung / drug therapy
Adenocarcinoma of Lung / immunology*
Adrenal Cortex Hormones / administration & dosage
Aged
Anti-Inflammatory Agents / administration & dosage
Antibodies, Monoclonal, Humanized / adverse effects
Antibodies, Monoclonal, Humanized / therapeutic use
Antineoplastic Agents / adverse effects
Antineoplastic Agents / therapeutic use
B7-H1 Antigen / immunology
B7-H1 Antigen / metabolism
Drug-Related Side Effects and Adverse Reactions / diagnosis
Drug-Related Side Effects and Adverse Reactions / immunology*
Flow Cytometry
Humans
Immunotherapy / adverse effects
Immunotherapy / methods*
Lung / drug effects*
Lung / immunology
Lung Neoplasms / diagnosis
Lung Neoplasms / drug therapy
Lung Neoplasms / immunology*
Lymphocytes, Tumor-Infiltrating / immunology*
Male
Middle Aged
Pneumonia / diagnosis
Pneumonia / etiology
Pneumonia / immunology*

Substances

Adrenal Cortex Hormones
Anti-Inflammatory Agents
Antibodies, Monoclonal, Humanized
Antineoplastic Agents
B7-H1 Antigen
CD274 protein, human
pembrolizumab