Abstract
Lypressin enhances the T-wave in the ECG of the anesthetized Sprague-Dawley rat and this has been used in screening for antianginal activity. After oral administration the durations of action of the organic nitrates, glyceryl trinitrate, isosorbide dinitrate, glyceryl 1,2-dinitrate, glyceryl 1,3-dinitrate and of SIN-1 (3-morpholinosydnonimine), molsidomine and nicorandil were shorter than those of verapamil and nifedipine. The sequence of the durations of action of the substances examined was the same in the rat as in man.
MeSH terms
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Administration, Oral
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Angina Pectoris / drug therapy
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Animals
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Coronary Vasospasm / chemically induced
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Coronary Vasospasm / drug therapy*
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Electrocardiography
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Hypoxia / drug therapy
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Isosorbide Dinitrate / administration & dosage
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Lypressin / pharmacology*
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Male
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Molsidomine / administration & dosage
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Molsidomine / analogs & derivatives
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Niacinamide / administration & dosage
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Niacinamide / analogs & derivatives
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Nicorandil
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Nifedipine / administration & dosage
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Nitroglycerin / administration & dosage
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Rats
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Rats, Inbred Strains
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Verapamil / administration & dosage
Substances
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Niacinamide
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Nicorandil
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Lypressin
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linsidomine
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Verapamil
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Molsidomine
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Nitroglycerin
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Nifedipine
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Isosorbide Dinitrate