IL1A (-889) gene polymorphism is associated with the effect of diet as a risk factor in Acne Vulgaris

J Cosmet Dermatol. 2019 Feb;18(1):333-336. doi: 10.1111/jocd.12516. Epub 2018 Mar 1.


Background: Despite the several studies suggesting the genetic basis of acne vulgaris, the exact genetic architecture of this very common condition is not yet clear.

Aim of the work: This study aimed to investigate the association between IL-1A (-889) gene polymorphism and acne vulgaris in a sample of patients.

Subjects and method: Blood samples from 100 patients with acne vulgaris and 100 healthy age, sex, and BMI matched controls were obtained. DNA samples were isolated from blood cells, and the PCR-RFLP method was used for genotyping.

Results: The genotype distributions of IL-1A (-889) polymorphism were as expected under Hardy-Weinberg equilibrium. T allele was predominant in the patients, while C allele predominated in the control subjects (P value < .001). The frequency of TT genotype in patients was significantly higher than in the control subjects (P value < .001). CT genotype was significantly more frequent in the control subjects compared to patients (P value < .001). Among the 47 patients who reported diet as a risk factor for triggering or exacerbating their lesions, 62.5% had TT genotype (P value = .038).

Conclusion: IL-1A (-889) gene polymorphism has a role in the pathogenesis of acne vulgaris. We suggest that the triggering or exacerbating effect of diet on acne may be related to IL-1A (-889) gene polymorphism.

Keywords: IL-1A gene polymorphism; acne; diet and acne.

MeSH terms

  • Acne Vulgaris / genetics*
  • Adolescent
  • Case-Control Studies
  • Diet*
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Interleukin-1alpha / genetics*
  • Male
  • Polymorphism, Genetic
  • Risk Factors
  • Young Adult


  • IL1A protein, human
  • Interleukin-1alpha