Uneven Braking Spins RNA Polymerase into a Pause

Mol Cell. 2018 Mar 1;69(5):723-725. doi: 10.1016/j.molcel.2018.02.013.


In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA.

Publication types

  • Comment

MeSH terms

  • DNA-Directed RNA Polymerases / genetics
  • Escherichia coli / genetics
  • Escherichia coli Proteins
  • Nucleic Acid Conformation
  • RNA, Bacterial*
  • Transcription, Genetic*
  • Transcriptional Elongation Factors


  • Escherichia coli Proteins
  • RNA, Bacterial
  • Transcriptional Elongation Factors
  • nusA protein, E coli
  • DNA-Directed RNA Polymerases