Uneven Braking Spins RNA Polymerase into a Pause

Irina Artsimovitch; Georgiy A Belogurov

doi:10.1016/j.molcel.2018.02.013

Uneven Braking Spins RNA Polymerase into a Pause

Mol Cell. 2018 Mar 1;69(5):723-725. doi: 10.1016/j.molcel.2018.02.013.

Authors

Irina Artsimovitch¹, Georgiy A Belogurov²

Affiliations

¹ Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, OH, USA. Electronic address: artsimovitch.1@osu.edu.
² Department of Biochemistry, University of Turku, Turku, Finland.

PMID: 29499129
DOI: 10.1016/j.molcel.2018.02.013

Abstract

In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA.

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MeSH terms

DNA-Directed RNA Polymerases / genetics
Escherichia coli / genetics
Escherichia coli Proteins
Nucleic Acid Conformation
RNA, Bacterial*
Transcription, Genetic*
Transcriptional Elongation Factors

Substances

Escherichia coli Proteins
RNA, Bacterial
Transcriptional Elongation Factors
nusA protein, E coli
DNA-Directed RNA Polymerases