Reversing Time: Ezh1 Deficiency Hastens Definitive Hematopoiesis

April C Apostol; Anna E Beaudin

doi:10.1016/j.stem.2018.02.006

Reversing Time: Ezh1 Deficiency Hastens Definitive Hematopoiesis

Cell Stem Cell. 2018 Mar 1;22(3):285-287. doi: 10.1016/j.stem.2018.02.006.

Authors

April C Apostol¹, Anna E Beaudin²

Affiliations

¹ School of Natural Sciences, University of California, Merced, Merced, CA, USA.
² School of Natural Sciences, University of California, Merced, Merced, CA, USA. Electronic address: abeaudin@ucmerced.edu.

PMID: 29499144
DOI: 10.1016/j.stem.2018.02.006

Abstract

The inability to derive multipotent hematopoietic stem cells in vitro stems in part from a limited understanding of how multipotency is acquired during development. Recently in Nature,Vo et al. (2018) reveal the epigenetic enzyme Ezh1 as a master regulator of multipotency during hematopoietic stem cell development.

Publication types

Comment

MeSH terms

Embryonic Development
Hematopoiesis*
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells*

Grants and funding

K01 HL130753/HL/NHLBI NIH HHS/United States