A critical role for IL-18 in transformation and maturation of naive eosinophils to pathogenic eosinophils

Sathisha Upparahalli Venkateshaiah; Akanksha Mishra; Murli Manohar; Alok K Verma; Priya Rajavelu; Rituraj Niranjan; Laurianne G Wild; Nereida A Parada; Uwe Blecker; Joseph A Lasky; Anil Mishra

doi:10.1016/j.jaci.2018.02.011

A critical role for IL-18 in transformation and maturation of naive eosinophils to pathogenic eosinophils

J Allergy Clin Immunol. 2018 Jul;142(1):301-305. doi: 10.1016/j.jaci.2018.02.011. Epub 2018 Mar 2.

Affiliations

¹ Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center (TEDC), Tulane University School of Medicine, New Orleans, La.
² Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center (TEDC), Tulane University School of Medicine, New Orleans, La; Elite Biosciences, Cleveland, Ohio.
³ Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁴ Department of Medicine, Section of Allergy and Immunology, Tulane University School of Medicine, New Orleans, La.
⁵ Department of Medicine, Section of Pediatric Gastroenterology, Tulane University School of Medicine, New Orleans, La.
⁶ Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Center (TEDC), Tulane University School of Medicine, New Orleans, La. Electronic address: amishra@tulane.edu.

Abstract

The current studies demonstrate a critical role of IL-18 in transforming IL-5 generated naïve eosinophils into the distinct inflammatory CD101⁺CD274⁺ expressing mature and activated tissue eosinophils that promote disease pathogenesis.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Animals
B7-H1 Antigen / immunology
Cell Differentiation / immunology
Echinocandins / immunology
Eosinophilic Esophagitis / immunology
Eosinophils / immunology*
Eosinophils / pathology*
Humans
Hypersensitivity / immunology*
Interleukin-18 / immunology*
Mice

Substances

B7-H1 Antigen
Echinocandins
Interleukin-18
Rezafungin

Grants and funding

R01 AI080581/AI/NIAID NIH HHS/United States