Cell Type-Specific Optogenetic Dissection of Brain Rhythms

Hillel Adesnik

doi:10.1016/j.tins.2018.01.001

Cell Type-Specific Optogenetic Dissection of Brain Rhythms

Trends Neurosci. 2018 Mar;41(3):122-124. doi: 10.1016/j.tins.2018.01.001.

Author

Hillel Adesnik¹

Affiliation

¹ Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA. Electronic address: hadesnik@berkeley.edu.

PMID: 29499773
DOI: 10.1016/j.tins.2018.01.001

Abstract

A pair of 2009 papers by Cardin et al. and Sohal et al. marked a watershed moment as optogenetics exploded onto the scene of systems neuroscience. This pair of back-to-back papers in the June issue of Nature leveraged a powerful combination of the Cre/lox system, adeno-associated viral gene vectors, and optogenetics to re-examine the circuit basis of neuronal synchronization.

Keywords: gamma rhythms; optogenetics; parvalbumin interneurons.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / metabolism
Brain / physiology*
Gamma Rhythm / physiology*
Humans
Interneurons / physiology
Neurons / physiology*
Optogenetics*
Parvalbumins / metabolism

Substances

Parvalbumins