Medical Management of Facial Redness in Rosacea

Dermatol Clin. 2018 Apr;36(2):151-159. doi: 10.1016/j.det.2017.11.010. Epub 2017 Dec 15.

Abstract

Persistent centrofacial erythema is a predominant component of rosacea. The authors review the topical and systemic treatments for rosacea-related erythema and flushing to aid in treatment decision making in clinical practice. Databases were searched for literature pertaining to treatment options for erythema related to rosacea. The paucity of large-scale clinical trials in patients with the erythematotelangiectatic rosacea subtype makes it difficult to draw firm conclusions regarding treatment. Although certain topical and oral treatments appear to have modest benefit in reducing erythema, there is a need for high-quality, well-designed, and rigorously reported studies for the treatments for rosacea.

Keywords: Erythema; Erythematotelangiectatic; Management; Papulopustular; Rosacea; Topical.

Publication types

  • Review

MeSH terms

  • Administration, Cutaneous
  • Adrenergic alpha-Agonists / therapeutic use*
  • Antihypertensive Agents / administration & dosage
  • Antihypertensive Agents / therapeutic use*
  • Brimonidine Tartrate / adverse effects
  • Brimonidine Tartrate / therapeutic use*
  • Calcineurin Inhibitors / therapeutic use
  • Erythema / drug therapy*
  • Erythema / etiology*
  • Face
  • Humans
  • Off-Label Use
  • Oxymetazoline / therapeutic use*
  • Retinoids / administration & dosage
  • Rosacea / complications*
  • Tetracyclines / therapeutic use

Substances

  • Adrenergic alpha-Agonists
  • Antihypertensive Agents
  • Calcineurin Inhibitors
  • Retinoids
  • Tetracyclines
  • Brimonidine Tartrate
  • Oxymetazoline