Rosacea Pathogenesis

Dermatol Clin. 2018 Apr;36(2):81-86. doi: 10.1016/j.det.2017.11.001. Epub 2017 Dec 15.


Rosacea is a chronic inflammatory skin disorder that is not fully understood but involves the complex interplay of genetic factors, immune dysregulation, neurovascular dysregulation, presence of microorganisms, and environmental factors. Increased activation of the immune system occurs through multiple stimuli, including increased levels of cathelicidin and kallikrein 5, Toll-like receptor 2, matrix metalloproteinases, and mast cells within the skin. Their effects are enhanced by the presence of microorganisms and external triggers, such as UV radiation.

Keywords: Cathelicidin; Demodex; Kallikrein; Mast cells; Matrix metalloproteinase.

Publication types

  • Review

MeSH terms

  • Humans
  • Rosacea / immunology*
  • Rosacea / metabolism
  • Rosacea / microbiology*
  • Transient Receptor Potential Channels / metabolism*
  • Ultraviolet Rays / adverse effects


  • Transient Receptor Potential Channels