Genetic Predisposition to Rosacea

Olabola Awosika; Elias Oussedik

doi:10.1016/j.det.2017.11.002

Genetic Predisposition to Rosacea

Dermatol Clin. 2018 Apr;36(2):87-92. doi: 10.1016/j.det.2017.11.002. Epub 2017 Dec 16.

Authors

Olabola Awosika¹, Elias Oussedik²

Affiliations

¹ Department of Dermatology, The George Washington Medical Faculty Associates, 2150 Pennsylvania Avenue Northwest, 2B-427, Washington, DC 20037, USA. Electronic address: olabolaa@gmail.com.
² Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.

PMID: 29499803
DOI: 10.1016/j.det.2017.11.002

Abstract

Rosacea is a common inflammatory skin disease with a multifaceted pathophysiology, including environmental stressors and neurovascular and immune dysfunction affected by the presence of pathogens. The genetic component of this disorder is not well understood. However, a possible genetic origin in Northern European descendants, family inheritance, twin concordance, and genetic associations with autoimmune disorders attest the genetic predisposition to rosacea. Currently, one single-nucleotide polymorphism has been identified in association with rosacea and is intergenic between HLA-DRA and BTNL2. Additional associations with HLA alleles and immune-mediated disorders support the role of immune-regulating genes and innate and adaptive immunity in rosacea.

Keywords: HLA-DRA; Human leukocyte antigen; Single-nucleotide polymorphism.

Publication types

Review

MeSH terms

Autoimmune Diseases / genetics
Genetic Predisposition to Disease*
Humans
Rosacea / genetics*
Transcription, Genetic*
Twin Studies as Topic