[Changes in the receptor link during the development of renal sensitivity to aldosterone and antidiuretic hormone]

Fiziol Zh SSSR Im I M Sechenova. 1986 Dec;72(12):1673-9.
[Article in Russian]


The aldosterone, cAMP and ADH receptors were studied in kidneys of 10-14- and 60-day old rats. Concentrations of aldosterone and cAMP receptors were reduced, while ADH binding was increased during the period of maturation of kidney functions. The investigation of the affinity and molecular weights of cAMP and ADH receptors suggests their complex nature and altering of their individual properties during ontogenesis. Aldosterone and cAMP with their receptors seem to participate in the regulation of gene activity in ontogenesis and ADH seems to participate in the formation of its own receptors.

Publication types

  • English Abstract

MeSH terms

  • Aging / physiology*
  • Aldosterone / metabolism
  • Animals
  • DNA / metabolism
  • Kidney Medulla / analysis*
  • Kidney Medulla / growth & development
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Angiotensin / analysis*
  • Receptors, Cyclic AMP / analysis
  • Receptors, Glucocorticoid / analysis*
  • Receptors, Glucocorticoid / metabolism
  • Receptors, Mineralocorticoid
  • Receptors, Vasopressin


  • Receptors, Angiotensin
  • Receptors, Cyclic AMP
  • Receptors, Glucocorticoid
  • Receptors, Mineralocorticoid
  • Receptors, Vasopressin
  • Aldosterone
  • DNA