ADC at 3.0 T as a noninvasive biomarker for preoperative prediction of Ki67 expression in invasive ductal carcinoma of breast

Clin Imaging. 2018 Nov-Dec;52:16-22. doi: 10.1016/j.clinimag.2018.02.010. Epub 2018 Feb 18.


Purpose: To investigate the role of apparent diffusion coefficient (ADC) as an imaging biomarker for invasive ductal carcinoma (IDC) in the breast.

Methods: Seventy-one patients undergoing 3.0 Tesla DWI were retrospectively enrolled. Correlations between the ADC values and prognostic factors were evaluated.

Results: Multivariate regression analyses showed that Ki67 expression and molecular subtype were independently associated with the ADC. Discriminant analysis excluded the ADC as a good biomarker for subtype, but the mean ADC significantly distinguished Ki67-positive (low ADC) from Ki67-negative (high ADC) lesions, as observed in the in ROC curves, with a diagnostic sensitivity of 1.00 and a cut-off value of 0.97 × 10-3 mm2/s.

Conclusion: The ADC may be helpful for predicting Ki67 expression in IDC preoperatively.

Keywords: Diffusion weighted imaging; Invasive ductal carcinoma; Ki67; Magnetic resonance imaging.

MeSH terms

  • Adult
  • Aged
  • Biomarkers
  • Breast / pathology*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology*
  • Carcinoma, Ductal, Breast* / metabolism
  • Diffusion Magnetic Resonance Imaging / methods*
  • Female
  • Humans
  • Ki-67 Antigen / metabolism*
  • Middle Aged
  • ROC Curve
  • Retrospective Studies


  • Biomarkers
  • Ki-67 Antigen