Medical Management of Otosclerosis

Norma de Oliveira Penido; Andy de Oliveira Vicente

doi:10.1016/j.otc.2017.11.006

Medical Management of Otosclerosis

Otolaryngol Clin North Am. 2018 Apr;51(2):441-452. doi: 10.1016/j.otc.2017.11.006.

Authors

Norma de Oliveira Penido¹, Andy de Oliveira Vicente²

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Mário Whateley 109/72, São Paulo, São Paulo 05083140, Brazil. Electronic address: nopenido@terra.com.br.
² Otorhinolaryngology Department, Hospital Especializado CEMA, Rua do Oratório, 1369 - Mooca, São Paulo-SP, 03117-000, Brazil.

PMID: 29502728
DOI: 10.1016/j.otc.2017.11.006

Abstract

Otosclerosis/otospongiosis is a primary osteodystrophy of the otic capsule that affects genetically predisposed individuals and leads to progressive hearing loss. Diagnosis is usually clinical, based on the findings of anamnesis, physical examination, and audiometric evaluation. However, high-resolution computed tomography scan and MRI have played an important role in the diagnosis and therapeutic approach of otosclerosis and in assisting in the differential diagnosis. The therapeutic approach is aimed at preventing, or at least minimizing, disease progression while attempting to restore hearing. The use of sodium fluoride and bisphosphonates can be an important adjunct, perhaps even primary treatment, in managing active lesions.

Keywords: Computed tomography; Hearing loss; MRI; Otosclerosis; Otospongiosis; Sodium alendronate; Sodium fluoride.

Publication types

Review

MeSH terms

Diphosphonates / therapeutic use*
Hearing Loss / etiology
Hearing Loss / prevention & control*
Hearing Tests
Humans
Magnetic Resonance Imaging
Otosclerosis / diagnostic imaging*
Otosclerosis / drug therapy*
Randomized Controlled Trials as Topic
Sodium Fluoride / therapeutic use*
Tomography, X-Ray Computed

Substances

Diphosphonates
Sodium Fluoride