A Prospective Cohort Study of Symptomatic Venous Thromboembolic Events in Foot and Ankle Trauma: The Need for Stratification in Thromboprophylaxis?

J Foot Ankle Surg. 2018 May-Jun;57(3):484-488. doi: 10.1053/j.jfas.2017.10.036. Epub 2018 Mar 2.

Abstract

The incidence of venous thromboembolic (VTE) events (deep vein thrombophlebitis [DVT] or pulmonary embolism [PE]) in foot and ankle trauma has been low, and the risk/benefit ratio associated with chemoprophylaxis is controversial. We compared the 90-day incidence of VTE events in 3 cohorts: group 1, tendo-Achillis (TA) ruptures managed with full weightbearing in a walker boot; group 2, ankle fractures immobilized non-weightbearing in a below-the-knee cast; and group 3, ankle fractures managed surgically, followed by non-weightbearing in a below-the-knee cast. Data were extracted from 2 prospectively collected trust databases for acute TA ruptures and ankle fractures. VTE risk was assessed using a U.K. national assessment tool. Chemoprophylaxis was prescribed for high-risk patients. The 90-day incidence of symptomatic VTE events was drawn from a trust-wide radiology database. In group 1 (n = 291), the incidence of VTE events was 4.8% (11 [3.8%] DVT, 3 [1.0%] PE) at a mean of 16.1 ± 6.8 days. In group 2 (n = 227), the incidence of VTE events was 2.2% (5 [2.2%] DVT) at a mean of 33.4 ± 11.3 days. In group 3 (n = 199), the incidence of VTE events was 3.0% (5 [2.5%] DVT, 1 [0.5%] PE) at a mean of 37.2 ± 14.2 days. Patients with symptomatic VTE events presented significantly earlier after acute TA rupture compared with after ankle fracture (p = .002). We found the overall incidence of VTE events in foot and ankle trauma was low, with a relatively greater incidence of symptomatic VTE events, which occurred earlier, in acute TA ruptures compared with ankle fractures.

Keywords: Achilles tendon; DVT; PE; deep vein thrombophlebitis; pulmonary embolism; tendo-Achillis; trauma.

Publication types

  • Comparative Study

MeSH terms

  • Achilles Tendon / injuries
  • Achilles Tendon / surgery
  • Adult
  • Ankle Fractures / diagnostic imaging
  • Ankle Fractures / surgery*
  • Ankle Injuries / diagnostic imaging
  • Ankle Injuries / surgery*
  • Anticoagulants / administration & dosage*
  • Cohort Studies
  • Databases, Factual
  • Female
  • Follow-Up Studies
  • Foot Injuries / diagnostic imaging
  • Foot Injuries / surgery
  • Fracture Fixation, Internal / adverse effects*
  • Fracture Fixation, Internal / methods
  • Humans
  • Injury Severity Score
  • Male
  • Middle Aged
  • Postoperative Complications / prevention & control
  • Prospective Studies
  • Pulmonary Embolism / prevention & control
  • Risk Assessment
  • Tendon Injuries / diagnostic imaging
  • Tendon Injuries / surgery*
  • Time Factors
  • Treatment Outcome
  • Venous Thromboembolism / prevention & control*
  • Young Adult

Substances

  • Anticoagulants