Management of Barrett's esophagus with low-grade dysplasia

Dis Esophagus. 2018 Apr 1;31(4). doi: 10.1093/dote/doy004.


Barrett's esophagus progresses to esophageal adenocarcinoma in a stepwise histological fashion of no dysplasia, low grade dysplasia, high grade dysplasia and cancer. Hence the progression to cancer from various histological stages is different. Progression to cancer from low grade dysplasia is highly variable in the literature due to high inter-observer variability between pathologists in diagnosing it. Studies have shown the utility of having confirmation of low grade dysplasia by expert pathologists or documenting its persistence on two subsequent endoscopies in order to unify the diagnosis. The treatment of low grade dysplasia is variable. In this article we summarize the diagnosis, evaluation and management of low grade dysplasia in Barrett's Esophagus.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy*
  • Barrett Esophagus / pathology
  • Barrett Esophagus / therapy*
  • Disease Management*
  • Disease Progression
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / therapy*
  • Esophagus / pathology*
  • Humans
  • Hyperplasia / pathology
  • Hyperplasia / therapy
  • Precancerous Conditions / pathology
  • Precancerous Conditions / therapy*

Supplementary concepts

  • Adenocarcinoma Of Esophagus