Expression of Ia antigens by murine kidney epithelium after exposure to streptozotocin

Am J Pathol. 1987 Mar;126(3):561-8.


In the normal murine kidney, Ia antigens are expressed by dendritic cells located within the interstitial connective tissue and scattered cells within the glomerulus. After receiving multiple low doses of streptozotocin, a nitrosourea derivative of glucose, kidney epithelium labeled intensely with anti-Ia antibodies. Ultrastructural immunohistochemistry indicated that the epithelial cells of the proximal convoluted tubules expressed Ia antigens on their basolateral surfaces while remaining Ia- on their luminal surfaces. This response to streptozotocin does not appear to be related to the diabetogenic potential of the drug, because BALB/cJ mice, which remain normoglycemic after treatment with streptozotocin, also exhibited strongly Ia+ tubular epithelium after treatment with streptozotocin.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / immunology*
  • Diabetes Mellitus, Experimental / pathology
  • Epithelium / immunology
  • Epithelium / ultrastructure
  • Histocompatibility Antigens Class II / analysis*
  • Hyperglycemia / chemically induced
  • Hyperglycemia / immunology
  • Kidney / immunology*
  • Kidney / ultrastructure
  • Male
  • Mice
  • Mice, Inbred Strains
  • Streptozocin / toxicity*


  • Histocompatibility Antigens Class II
  • Streptozocin