Arabidopsis thaliana homeodomain-leucine zipper type I transcription factors contribute to control leaf venation patterning

Plant Signal Behav. 2018 Mar 4;13(3):e1448334. doi: 10.1080/15592324.2018.1448334. Epub 2018 Mar 22.


Venation patterning is a taxonomic attribute for classification of plants and it also plays a role in the interaction of plants with the environment. Despite its importance, the molecular physiology controlling this aspect of plant development is still poorly understood. Auxin plays a central role modulating the final vein network and patterning. This addendum discusses recent findings on the role of homeodomain-leucine zipper (HD-Zip) transcription factors on the regulation of leaf venation patterning. Moreno-Piovano et al. reported that ectopic expression of a sunflower HD-Zip I gene, HaHB4, increased the asymmetry of leaf venation. Even more, this work showed that auxin transport in the leaf through LAX carriers controls venation patterning. Here, we provide evidence indicating that some Arabidopsis thaliana HD-Zip I genes play a role in the determination of the final leaf venation patterning. We propose that these genes contribute to regulate vein patterning, likely controlling auxin homeostasis.

Keywords: AUX/LAX; Auxin influx carriers; HD-Zip I; hierarchy; patterning; venation symmetry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / embryology*
  • Arabidopsis / genetics
  • Arabidopsis Proteins / metabolism*
  • Body Patterning* / genetics
  • Genes, Plant
  • Homeodomain Proteins / metabolism*
  • Leucine Zippers*
  • Mutation / genetics
  • Plant Leaves / embryology*
  • Plant Leaves / genetics
  • Transcription Factors / metabolism*


  • Arabidopsis Proteins
  • Homeodomain Proteins
  • Transcription Factors

Grants and funding

Agencia Nacional de Promociín Científica y Tecnológica, Consejo Nacional de Investigaciones Científicas y Técnicas and Universidad Nacional del Litoral.