Neurological and Psychiatric Disorders in Psoriasis

Rev Neurosci. 2018 Sep 25;29(7):805-813. doi: 10.1515/revneuro-2017-0108.


Psoriasis used to be known as a skin disorder; however, it can now be considered as a systemic disease with the involvement of multiple organs. Neurological and psychiatric disorders are some of the associated problems that can be observed in patients with psoriasis. Stroke, multiple sclerosis, seizure, migraine, restless leg syndrome, Parkinson's disease, Guillain-Barré syndrome, and myasthenia gravis are the reported neurological diseases, while depression, bipolar mood disorder, anxiety, psychosis, cognitive impairment, personality disorders, sexual disorders, sleep disturbance, and eating disorders are the recognized psychiatric presentations in patients with psoriasis. Herein, the neurological and psychiatric disorders of psoriasis are described.

Keywords: Parkinson’s disease; anxiety; depression; migraine; multiple sclerosis; myasthenia gravis; psoriasis; psychosis; seizure; stroke.

Publication types

  • Review

MeSH terms

  • Humans
  • Mental Disorders / complications*
  • Nervous System Diseases / complications*
  • Psoriasis / etiology*