Myosin 10 is involved in murine pigmentation

Exp Dermatol. 2019 Apr;28(4):391-394. doi: 10.1111/exd.13528. Epub 2018 Apr 24.


Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for Myo10 in pigmentation, with a phenotype unlike those of Myo5a or Myo7a. Adult mice homozygous for a disrupted Myo10 allele on a C57BL/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. Myo10 has previously been implicated in human pigmentation. Our current study reveals involvement of Myo10 in murine skin pigmentation.

Keywords: hair follicles; melanocytes; myosin; pigmentation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Female
  • Gene Expression
  • Hair Color / genetics
  • Hair Follicle / pathology*
  • Male
  • Melanocytes / metabolism
  • Melanocytes / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myosins / genetics*
  • Penetrance
  • Pigmentation Disorders / genetics*
  • Pigmentation Disorders / pathology
  • Skin Pigmentation / genetics*
  • Syndactyly / genetics


  • Myo10 protein, mouse
  • Myosins