Potential Role of Inorganic Confined Environments in Prebiotic Phosphorylation

doi:10.3390/life8010007

. 2018 Mar 5;8(1):7.

doi: 10.3390/life8010007.

Potential Role of Inorganic Confined Environments in Prebiotic Phosphorylation

Avinash Vicholous Dass¹, Maguy Jaber², André Brack³, Frédéric Foucher⁴, Terence P Kee⁵, Thomas Georgelin^{6

7}, Frances Westall⁸

Affiliations

¹ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. avinash-vicholous.dass@cnrs-orleans.fr.
² Laboratoire d'Archelologie Moléculaire et Structurale, Sorbonne Universités, UPMC Paris 06, CNRS UMR 8220, 4 place Jussieu, F-75005 Paris, France. maguy.jaber@upmc.fr.
³ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. andre.brack@cnrs-orleans.fr.
⁴ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. frederic.foucher@cnrs.fr.
⁵ School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK. t.p.kee@leeds.ac.uk.
⁶ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. thomas.georgelin@upmc.fr.
⁷ Laboratoire de Réactivité de Surface, Sorbonne Universités, UPMC Paris 06, CNRS UMR 7197, 4 place Jussieu, F-75005 Paris, France. thomas.georgelin@upmc.fr.
⁸ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. frances.westall@cnrs-orleans.fr.

PMID: 29510574
PMCID: PMC5871939
DOI: 10.3390/life8010007

Free PMC article

Potential Role of Inorganic Confined Environments in Prebiotic Phosphorylation

Avinash Vicholous Dass et al. Life (Basel). 2018.

Free PMC article

. 2018 Mar 5;8(1):7.

doi: 10.3390/life8010007.

Authors

Avinash Vicholous Dass¹, Maguy Jaber², André Brack³, Frédéric Foucher⁴, Terence P Kee⁵, Thomas Georgelin^{6

7}, Frances Westall⁸

Affiliations

¹ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. avinash-vicholous.dass@cnrs-orleans.fr.
² Laboratoire d'Archelologie Moléculaire et Structurale, Sorbonne Universités, UPMC Paris 06, CNRS UMR 8220, 4 place Jussieu, F-75005 Paris, France. maguy.jaber@upmc.fr.
³ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. andre.brack@cnrs-orleans.fr.
⁴ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. frederic.foucher@cnrs.fr.
⁵ School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK. t.p.kee@leeds.ac.uk.
⁶ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. thomas.georgelin@upmc.fr.
⁷ Laboratoire de Réactivité de Surface, Sorbonne Universités, UPMC Paris 06, CNRS UMR 7197, 4 place Jussieu, F-75005 Paris, France. thomas.georgelin@upmc.fr.
⁸ Centre de Biophysique Moléculaire (CBM), Centre National de la Recherche Scientifique (CNRS), Rue Charles Sadron, 45071 Orléans, France. frances.westall@cnrs-orleans.fr.

PMID: 29510574
PMCID: PMC5871939
DOI: 10.3390/life8010007

Abstract

A concise outlook on the potential role of confinement in phosphorylation and phosphate condensation pertaining to prebiotic chemistry is presented. Inorganic confinement is a relatively uncharted domain in studies concerning prebiotic chemistry, and even more so in terms of experimentation. However, molecular crowding within confined dimensions is central to the functioning of contemporary biology. There are numerous advantages to confined environments and an attempt to highlight this fact, within this article, has been undertaken, keeping in context the limitations of aqueous phase chemistry in phosphorylation and, to a certain extent, traditional approaches in prebiotic chemistry.

Keywords: hydrogels; interface; nanoscopic confinement; phosphorylation; prebiotic chemistry.

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Conflict of interest statement

The author declares no conflicts of interest.

Figures

**Figure 1**
Water types in confined system.

**Figure 2**
Cryosem image of silica hydrogel prepared by a sol/gel methods from a mixture of sodium silicate and acetic acid solutions. Pore size around 2 µm.

See this image and copyright information in PMC

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References

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1. Grover M., He C., Hsieh M.-C., Yu S.-S. A Chemical Engineering Perspective on the Origins of Life. Processes. 2015;3:309–338. doi: 10.3390/pr3020309. - DOI
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[1] Trevors J.T., Pollack G.H. Hypothesis: The origin of life in a hydrogel environment. Prog. Biophys. Mol. Biol. 2005;89:1–8. doi: 10.1016/j.pbiomolbio.2004.07.003. - DOI - PubMed

[2] Trevors J.T., Pollack G.H. Hypothesis: The origin of life in a hydrogel environment. Prog. Biophys. Mol. Biol. 2005;89:1–8. doi: 10.1016/j.pbiomolbio.2004.07.003. - DOI - PubMed

[3] Ellis R.J. Macromolecular crowding: An important but neglected aspect of the intracellular environment. Curr. Opin. Struct. Biol. 2001;11:114–119. doi: 10.1016/S0959-440X(00)00172-X. - DOI - PubMed

[4] Ellis R.J. Macromolecular crowding: An important but neglected aspect of the intracellular environment. Curr. Opin. Struct. Biol. 2001;11:114–119. doi: 10.1016/S0959-440X(00)00172-X. - DOI - PubMed

[5] Grover M., He C., Hsieh M.-C., Yu S.-S. A Chemical Engineering Perspective on the Origins of Life. Processes. 2015;3:309–338. doi: 10.3390/pr3020309. - DOI

[6] Grover M., He C., Hsieh M.-C., Yu S.-S. A Chemical Engineering Perspective on the Origins of Life. Processes. 2015;3:309–338. doi: 10.3390/pr3020309. - DOI

[7] Ricci M.A., Bruni F., Gallo P., Rovere M., Soper A.K. Water in confined geometries: Experiments and simulations. J. Phys. Condens. Matter. 2000;12:A345. doi: 10.1088/0953-8984/12/8A/346. - DOI

[8] Ricci M.A., Bruni F., Gallo P., Rovere M., Soper A.K. Water in confined geometries: Experiments and simulations. J. Phys. Condens. Matter. 2000;12:A345. doi: 10.1088/0953-8984/12/8A/346. - DOI

[9] Venables D.S., Huang K., Schmuttenmaer C.A. Effect of reverse micelle size on the librational band of confined water and methanol. J. Phys. Chem. B. 2001;105:9132–9138. doi: 10.1021/jp0112065. - DOI

[10] Venables D.S., Huang K., Schmuttenmaer C.A. Effect of reverse micelle size on the librational band of confined water and methanol. J. Phys. Chem. B. 2001;105:9132–9138. doi: 10.1021/jp0112065. - DOI

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Potential Role of Inorganic Confined Environments in Prebiotic Phosphorylation

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Potential Role of Inorganic Confined Environments in Prebiotic Phosphorylation

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