A simple diagnostic test for pupillary abnormality in diabetic autonomic neuropathy

Diabet Med. 1986 Jan;3(1):38-41. doi: 10.1111/j.1464-5491.1986.tb00703.x.


A simple portable pupillometer using Polaroid photography has been developed for use in the diagnosis of diabetic autonomic neuropathy. The pupil diameter per cent (PD%), defined as the percentage of iris diameter to which pupil diameter had dilated in darkness, was measured from the instant colour prints. An age-related normal range was constructed from measurements in 163 healthy subjects in whom PD% declined linearly by 3% per decade. The PD% was measured in 15 patients with automatic neuropathy and 12 were identified with abnormally low values indicating a failure of sympathetically mediated dilatation. Results were consistent with the standard television pupillometric technique and had the same high repeatability with a coefficient of variation of 3.2%.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Autonomic Nervous System Diseases / diagnosis*
  • Autonomic Nervous System Diseases / physiopathology
  • Darkness
  • Diabetic Neuropathies / diagnosis*
  • Diabetic Neuropathies / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Photography* / instrumentation
  • Pupil / physiology*
  • Pupil / physiopathology
  • Reference Values
  • Sympathetic Nervous System / physiopathology