Value of the eazyplex ® CSF direct assay in rapid diagnosis of invasive meningococcal disease - Case report

Acta Microbiol Immunol Hung. 2018 Aug 1;65(3):309-315. doi: 10.1556/030.65.2018.021. Epub 2018 Mar 7.

Abstract

There is a need for easy-to-use molecular assays for diagnosis of invasive meningococcal disease. Here, we report the rapid identification of Neisseria meningitidis in a cerebrospinal fluid sample from a patient with purulent meningitis using a commercially available loop-mediated isothermal amplification assay, resulting in a prompt de-escalation of the initial empiric antibiotic therapy.

Keywords: LAMP; Neisseria meningitidis; invasive meningococcal disease.

Publication types

  • Case Reports

MeSH terms

  • Cerebrospinal Fluid / microbiology*
  • DNA, Bacterial / genetics
  • Female
  • Humans
  • Meningococcal Infections / cerebrospinal fluid
  • Meningococcal Infections / diagnosis*
  • Meningococcal Infections / microbiology
  • Neisseria meningitidis / classification
  • Neisseria meningitidis / genetics
  • Neisseria meningitidis / isolation & purification*
  • Nucleic Acid Amplification Techniques / economics
  • Young Adult

Substances

  • DNA, Bacterial